<b>Background:</b> Results of clinical trials may not reflect the benefits of asthma biologics in real-world settings. <b>Objective:</b> To describe clinical remission following initiation of biologics in adults with severe asthma in ISAR. <b>Methods:</b> This multi-country (n=23), registry-based study included patients ≥18 years who initiated treatment with biologics (anti-IL5/5R, anti-IgE, anti-IL4/IL13). Remission during the 1 year (min. 6 months) post-initiation was defined as a composite of 2, 3, or 4 endpoints: no exacerbations, no long-term OCS (LTOCS) use, partly/well controlled asthma, and predicted normal (p.n.FEV1) ≥80%. Alternative definitions of remission using ≤1 exacerbation and ≤5 mg/day LTOCS were also explored. <b>Results:</b> Of 3348 eligible adults, median age was 54 years, 61.6% were female. At baseline vs post-initiation, 23.3% vs 54.7% had no exacerbation, 66.7% vs 79.3% did not require LTOCS, 9.3% vs 32.7% had well-controlled asthma, and 43.0% vs 46.4% had p.n.FEV1≥80%. Remission in 4 endpoints was achieved in 18.7% and 26.3% patients using the strict and alternative definitions (Figure 1). <b>Conclusion:</b> About one-in-five adults with severe asthma met criteria for clinical remission in all 4 endpoints following biologic initiation. The findings suggest that biologics can achieve remission in the real-world, however, medical unmet need remains among some patients with the current treatment paradigm.