BACKGROUND/AIMS: To assess the effectiveness of continuous care based on the Roy Adaptation Model (RAM) in patients undergoing total knee replacement (TKR) surgery. MATERIALS AND METHODS:This quasi-experimental study included 83 patients in a university hospital.The intervention group was offered continuous care based on RAM.The research data were collected using a Patient Identification Form, the Western Ontario and McMaster Universities Osteoarthritis Index, and the Hospital Anxiety and Depression Scale. RESULTS:Except for the pain score, no statistically significant difference in the pre-discharge and 3 rd month was found for the patients in the intervention and control groups.It was determined that the pain scores of patients in the intervention group in the pre-discharge period were lower than those in the control group (p=0.022)A significant difference was found between the anxiety score averages in time in the intervention group in terms of the group time interaction (p=0.009).Because of further analysis, a statistically significant difference was determined that the anxiety scores of patients in the intervention group in the 3 rd month were lower than those in the control group (p=0.032).A significant difference was found between the depression score averages in time in the intervention group in terms of the group x time interaction (p=0.037). CONCLUSION:The functional status and pain of patients improve over time.In this process, continuous care based on RAM was effective in developing effective adaptation behaviors of patients, and a positive effect on pain, anxiety, and depression was determined.