Background: Nursing educators are warned to determine the effects on student outcomes of changes in nursing education during the pandemic process and to be prepared for possible pandemics.Aim: This study aimed to evaluate the factors that affect the blood pressure skill scores, E-learning styles, and blood pressure measurement skill levels of nursing students in distance education. Methods:This was a descriptive study.This study was conducted between January and April 2021 with 2 nd -year nursing students at a public university.The data were collected using a descriptive information form, the e-learning styles scale, a video recording of students' blood pressure measurement skills, and a blood pressure skill checklist.Mann-Whitney U-test and Kruskal-Wallis test were used to evaluate the difference in blood pressure measurement skill scores. Results:The mean age of the students was 20.04 ± 1.53 years.Of them, 82.6% were female and 65.2% preferred YouTube for skill training.The mean scores of blood pressure measurement skill of students were 14.61 ± 5.04.Students mostly had independent (66.3%), logical (63%), and audiovisual (44.6%) dominant e-learning styles.The blood pressure measurement skill scores of the students, who are female, have 75-100% synchronous course attendance, and have an independent e-learning style were significantly higher.There was difference between students' blood pressure skill scores and independent e-learning styles. Conclusion:In distance education, nursing students' blood pressure measurement skills are insufficient and should be compensated by face-to-face education.Blood pressure skill self-instruction videos can support laboratory practices in a distance/hybrid nursing education platform.