BACKGROUND: The aesthetics standards for the male and female body fluctuate among different populations, hence Aesthetic Body Sculpting has to adjust accordingly to suit the patient preferences and expectations. One of the pillars in which Dynamic Definition Liposculpture (HD2) stands on is Fat Grafting, which nowadays include the concepts of power muscles and definition muscles. The latter are subject to demarcation and careful carving during surgery, while the former benefit as well from Fat Grafting in order to improve their volume and projection, and as a consequence, the anatomic, athletic, and youthful contour. We carried out a retrospective cohort including patients who underwent fat grafting of different muscles during HD2 including: The trapezius, the latissimus dorsi, the erector spinae, the pectorals, the breasts, the rectus abdominis muscle, the gluteus medius, above the gluteus major (SQ), the deltoids, the biceps, the triceps, the vastus medialis/lateralis, the biceps femoris, and/or the calves. METHODS: We performed cadaveric dissections for each anatomical region in order find the main pedicle for each muscle and as a result design a safe and reproducible fat grafting technique. Furthermore, we looked into our records for patients who underwent fat grafting in addition to HD2 from January 2017 to February 2022. Criteria for inclusion were any patient undergoing fat grafting of any/multiple muscles as part of HD2 procedures. RESULTS: A total of 1192 patients consecutive patients met the inclusion criteria. About 1020 (85%) were women and 172 (15%) were men. Anatomic regions subject to fat grafting included the posterior torso (5%), the upper limbs (14%), the anterior torso (37%), the gluteal region (94%) and the lower limbs (10%). Adipose graft volumes ranged from 40 to 650 cc (Avg = 250 cc). Only three cases of cellulitis were reported (0.3%), they were treated with oral antibiotics and physical means. Hematoma was reported in 5 cases (0.4%), which solved with conservative measures. No other complications were reported related to fat grafting. Almost all patients were satisfied with the procedure (95%). Follow up period ranged from 2 to 48 months. CONCLUSION: Liposuction might not be enough to achieve either the ideal muscularization of the male's body or the voluptuous/slim figure of the female anatomy. In such cases, fat grafting has become the cornerstone to achieve the desired body contour. The proper recognition of the main neurovascular pedicle from each muscle subject to fat grafting, the accurate preoperative markings and a meticulous surgical technique ensure both the safety and the reproducibility of our techniques. The high satisfaction index and the low rate of complications support our findings and encourage future studies to broaden the targeted population with a multicenter approach.