The World Health Organization (WHO) considered COVID-19 for more than three years a public health emergency of international concern (PHEIC) at a pandemic level. After a cumulate of 770,875,433 confirmed cases, including 6,959,316 deaths (up to September 19, 2023), fortunately, the COVID-19 mortality burden has significantly decreased in the last year (2022–2023) primarily due to effective vaccination (a total of 13,505,262,477 doses have been administered globally) (https://covid19.who.int/), despite Omicron and its sublineage variants' emergence [1,2]. However, the vaccine allocation was not as smooth as everyone would have liked, considering shortages or difficulties in promptly obtaining the vaccines for several countries, especially low- and middle-income countries (LMIC). In some cases, that led to the necessity of applying different strategies, such as extending the time interval in which the second dose was administered. Here, we present a perspective on implementing this vaccination strategy, particularly in low-income (LIC) and LMIC countries facing future pandemics.