We thank the authors for reaching out with their comments. When conducting our review on The Classic "Review of Dohan Eherenfest et al. (2009) on "Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)" [1Dohan Ehrenfest D.M. Rasmusson L. Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).Trends Biotechnol. 2009 Mar; 27: 158-167https://doi.org/10.1016/j.tibtech.2008.11.009Abstract Full Text Full Text PDF PubMed Scopus (1179) Google Scholar, 2Marín Fermín T. Calcei J.G. Della Vedova F. Martinez Cano J.P. Arias Calderon C. Imam M.A. Khoury M. Laupheimer M.W. D'Hooghe P. Review of Dohan Eherenfest et al(2009) on "Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).J ISAKOS. 2023 Aug 8; (S2059-7754(23)00545-X)https://doi.org/10.1016/j.jisako.2023.07.010Abstract Full Text Full Text PDF Scopus (0) Google Scholar] we had no intention to favor any classification over others but highlighting the role of each one in improving our current knowledge in orthobiologics. We apologize for missing Kon et al. coding system [3Kon E. Di Matteo B. Delgado D. Cole B.J. Dorotei A. Dragoo J.L. Filardo G. Fortier L.A. Giuffrida A. Jo C.H. Magalon J. Malanga G.A. Mishra A. Nakamura N. Rodeo S.A. Sampson S. Sánchez M. Platelet-rich plasma for the treatment of knee osteoarthritis: an expert opinion and proposal for a novel classification and coding system.Expert Opin Biol Ther. 2020 Dec; 20: 1447-1460https://doi.org/10.1080/14712598.2020.1798925Crossref PubMed Scopus (93) Google Scholar] and assure the experts involved in this classification system that it was an innocent omission without intentional harm. The impact of this paper can be attested without any doubt by its astonishing metrics, and we hope the proposed Universal Coding System will answer the current lack of reporting quality among orthobiologics studies. However, it is essential to note that by the time we reply to this letter, around twenty to thirty publications have reported their platelet-rich plasma composition using this classification from over 350 clinical trials indexed in PubMed conducted over that period. Thus, we must still promote guideline adoption among editors and reviewers as part of the submission and peer-review process as the next step toward our shared goal [4Marín Fermín T. Scarlat M.M. Laupheimer M.W. Would you have an injection without knowing its formula? New challenges in platelet-rich plasma therapy.Int Orthop. 2022 Oct; 46: 2179-2180https://doi.org/10.1007/s00264-022-05566-zCrossref PubMed Scopus (3) Google Scholar, 5Marín Fermín T. Papakostas E. Macchiarola L. Zampeli F. Kalifis G. De Girolamo L. Zikria B.A. Khoury M. D'Hooghe P. Injectable orthobiologics in professional football (Soccer) players: A systematic review.The Journal of Cartilage & Joint Preservation. 2022; 2100050https://doi.org/10.1016/j.jcjp.2022.100050Abstract Full Text Full Text PDF Scopus (2) Google Scholar]. ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.