Three new species of Stenospermation from Central Andes in Colombia are described: Stenospermation albifolium Castaño-Rubiano, S. melidae Castaño-Rubiano & Sierra-Giraldo and S. selvaflorensis Castaño-Rubiano, L. Ibañez & A. Zuluaga. The species are distributed in the eastern zone of Caldas and Antioquia departments, in Natural National Park Selva de Florencia, and in forest near to corregimiento de Berlin (Samaná-Caldas), at elevations between 653 and 1700 m a.s.l., as well as in Carmen del Vivoral (Antioquia) at 1087 m a.s.l. The new species are compared with the morphologically closest taxa and comments are made on their phenology.