ABSTRACTObjective To review the prevalence, incidence, and risk factors for developing anti-drug antibodies (AAA) in patients with non-infectious uveitis (NIU) treated with Adalimumab (ADA).Methods A systematic literature search was performed on PubMed, EMBASE, Virtual Health Library, Cochrane, and medRxiv. Meta-analysis was performed using random effects.Results Nine out of 2,373 studies were included. The prevalence of AAA in NIU patients treated with ADA was 9% (95% CI: 2% to 37%, I2 = 95% with a P<0.01), it was significantly higher in real-life scenarios (observational studies) than in clinical trials. The pooled incidence at 12 months was 27% (CI 95% 16%-42% I2 = 0%). Several factors have been associated with AAA generation in NIU patients, including the non-use of concomitant immunosuppressants, presence of autoimmune systemic disease, female gender, etc.Conclusion This study showed that AAA prevalence is higher in real-life scenarios compared to clinical trials. Further research is needed to elucidate the factors that trigger AAA generation in NIU patients.KEYWORDS: Adalimumabanti-drug antibodybiological therapyimmunogenicitynon-infectious uveitis AcknowledgmentsWe thank Dr. Gilma Hernandez for supporting the initial phase of the systematic revision, and Paola Andrea Ramirez Perez, from Universidad de Antioquia, an expert in literature searches certified by Cochrane, for her help reviewing the literature search used in the present study.Disclosure statementNo potential conflict of interest was reported by the author(s).Author contributionsCC and DIPS performed search strategy. Pairs of review authors (CC, GM, JP, LP, LZ, WR) examined the articles based on inclusion criteria. DIPS and ADLT resolved article selection conflicts. All authors drafted the manuscript. DIPS, ADLT and CC, reviewed the manuscript. All authors approved the final version submitted for publication.Data availability statementAdditional data is available from the corresponding author on request.Ethics declarationsEthics approval and consent for participation and publication: not applicable.Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/09273948.2023.2256850Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.