Background This paper is part of a large study which aimed to conduct a global comparative analysis of the extent to which established parameters for effective priority setting were incorporated into COVID-19 pandemic response planning in 86 countries representing all six regions of the WHO. Methods We performed a quantitative descriptive analysis to explore if and how countries' type of health system, political, and economic contexts impacted the inclusion of the parameters of quality priority setting in their COVID-19 pandemic plans. Results The countries sampled represent nations in AFRO, EMRO, EURO, PAHO, SEARO, and WPRO. No pattern in attention to PS quality indicators emerged by WHO region or country income levels. Evidence of political will, stakeholder participation, and use of scientific evidence/ adoption of WHO recommendations were each found in over 80% of plans. However, less than 10% of the plans described a specific PS process and a description of means for enhancing compliance with the decisions. Conclusion The global comparative analysis demonstrated that there was limited integration of parameters of quality priority setting in the pandemic planning and preparedness plans across the globe. Policy makers could start with a focus on identified areas, as they work towards integrating systematic Priority setting in their routine decision-making processes.