PURPOSE: The scientific and athletic communities are interested in studying factors influencing physical performance. Numerous strategies have been tried and evaluated to enhance athletic performance and recovery both during and after effort. Cooling is a therapeutic technique to either improve athletic performance or lessen muscle aches and pains. Compared with cooling before (pre-cooling) and after (post-cooling) aerobic and anaerobic activity, cooling while exercising, called per-cooling, has been proven to have considerable effects on physical performance. This study sought to ascertain how inter-series per-cooling affected skin temperature (Tsk), brachial circumference (BC), perceived exertion (RPE), and performance (nRep) during biceps curls. METHODS: A total of 22 participants enrolled in a counterbalanced and randomized experimental study. Participants were randomly divided into experimental (3 min cold water immersion, 10 °C) and control (3 min rest with elbows at 120°) groups. Each participant completed a warm-up of 2x10 (80%/1RM) biceps curls with 180 s rest between series. Following the activation, the participants performed three sets of repetitions until exhaustion. A mixed analysis of variance (MANOVA) was performed for each variable (3/4 measure × 2 groups, as appropriate) to explore mean differences between groups. RESULTS: Tsk was higher in the control group after each set (F = 48.5, p < 0.01), but no baseline differences were found. The nRep did not vary between groups, but there was a decrease in nRep in both groups across the sets (F = 76.4, p < 0.01). Also, BC (F = 19.7, p < 0.01) and RPE (F = 692.5, p < 0.01) increased gradually throughout the sets in both groups. CONCLUSIONS: Despite a decrease in Tsk due to the precooling during the curl biceps, no differences between groups were found for RPE, nRep, or BC. The authors recommend further studies to analyze whether the decrease in brachial temperature resulting from per-cooling could impact the post-exercise inflammation response leading to improved recovery instead of performance.