In the current COVID-19 pandemic, unusual manifestations such as rhabdomyolysis and acute encephalomyelitis have been described. One of the atypical presentations of COVID-19 is hiccups, which are involuntary repetitive contractions of the intercostal muscles and diaphragm, whose origin can be gastrointestinal, neurogenic, or infectious due to tuberculosis, influenza, among others. This report describes the cases of two patients in whom the main symptom for the diagnosis of SARS-CoV-2 infection, was hiccups associated with a pattern of bilateral pulmonary involvement; a review of the literature is included. Keywords: Singulto; hiyccups; COVID-19; SARS-CoV-2; atypical manifestations.