A bstract The first measurement of the top quark pair ( $$ \textrm{t}\overline{\textrm{t}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> ) production cross section in proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 . 6 TeV is presented. Data recorded with the CMS detector at the CERN LHC in Summer 2022, corresponding to an integrated luminosity of 1 . 21 fb − 1 , are analyzed. Events are selected with one or two charged leptons (electrons or muons) and additional jets. A maximum likelihood fit is performed in event categories defined by the number and flavors of the leptons, the number of jets, and the number of jets identified as originating from b quarks. An inclusive $$ \textrm{t}\overline{\textrm{t}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> production cross section of 881 ± 23 (stat + syst) ± 20 (lumi) pb is measured, in agreement with the standard model prediction of $$ {924}_{-40}^{+32} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mn>924</mml:mn> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>40</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>32</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> pb.