Introduction: Poisoning in children is an important and preventable cause of morbidity and mortality worldwide.Acetaminophen is the main drug responsible for unintentional poisoning in children under 12 years of age worldwide.In Colombia, information on this type of poisoning is scarce.The aim of this study was to describe the pattern of acute acetaminophen poisoning in children aged 0 to 12 years reported to SIVIGILA in Colombia from 2016 to 2019.Methodology: retrospective observational study, all cases of acute acetaminophen poisoning in children aged from 0 to 12 years reported to SIVIGILA from December 27,