Introduction: In young patients the spectrum of diseases that can cause a stroke is very limited. Methods: Retrospective study of a hospital in Northwestern Colombia in which the characteristics of a cohort of young patients under 40 years of age with a diagnosis of cerebrovascular disease. Medical records were reviewed during a follow-up from 2012-2022. Quantitative variables are presented as mean ± standard deviation or median according to their distribution, and qualitative variables as percentages. Results: A total of 23 patients were found, 18 female, 5 male. The average age at the time of the event was 28+11 years. Within the etiology 19 had a secondary cause of thrombophilia identified by corresponding studies. In the remaining 3, vascular malformation was found. Conclusions: the findings reported here highlight an important frequency of thrombophilic causes as responsible of stroke. We highlight the importance of a better characterization of our Latin American populations.