ABSTRACT Background Breast cancer is a global public health problem, representing a significant burden at the personal, collective, economic and quality of life level. It is necessary to consider the incidence, prevalence and mortality of this disease with a regional approach, so the objective of this work is to describe the epidemiological behavior of this tumor in the departments of the Colombian Caribbean Region during the period 2018 to 2021. Methodology Descriptive, retrospective study. Data from a secondary source (Cuenta de Alto Costo) was taken through the Higia platform. Rates x 100,000 of proportion of new cases reported, prevalence and incidence, by departments are analyzed. Data was imported from a downloadable.csv file into Excel and then into SPSS V22. Results The indicators analyzed showed a heterogeneous behavior in the 8 departments of the Region. Atlántico and Bolívar were the departments with similar and higher figures in the 4 years observed than those of the country and there were atypical values in San Andrés. La Guajira was the only department with a sustained tendency to increase in incidence, prevalence and mortality.