<h3>Introduction</h3> Few studies have compared the Pipeline Shield stents with previous generations of flow-diverting stents (FDs) for treating unruptured intracranial aneurysms (IA). <h3>Aim of Study</h3> This study aimed to evaluate the efficacy and safety of Pipeline Shield stents and FDs without modified surfaces. <h3>Methods</h3> The present evaluation is a retrospective cohort study of patients endovascularly treated for unruptured IA. The data analyzed was obtained from the anonymized database of the institution's Interventional Radiology service. <h3>Results</h3> The aneurysms treated with Pipeline Shield stents had higher six-month (OKM D; 87.5% vs. 71.4%, p-value: 0.025) and one-year (OKM D; 82.5% vs. 63.0%, p-value: 0.047) occlusion rates than aneurysms treated using FDs without modified surfaces. No differences between the devices were found at the one-year follow-up in ischemic stroke (p-value: 0.939) and hemorrhagic complications (p-value: 0.559). <h3>Conclusion</h3> The treatment with Pipeline Shield stent was as safe as with FD stent without modified surfaces. However, they showed a greater occlusion efficacy during one-year evaluation period. <h3>Disclosure of Interest</h3> othing to disclose