In an area of innovation, combination products are pharmaceutical options that involve a mixture of different compounds, including drugs, devices, and biologics, that could be integrated or nonintegrated in presentation. This aims to improve, potentiate, and facilitate many pharmaceutical targets, mechanisms of action, but also patient adherence, efficacy, and safety. These technologies are constantly advancing to offer pharmaceutical alternatives that preserve and potentiate the benefits of the components of each product. Regulating combination products requires quality and standards for each part of them, driven by regulatory entities that verify the safety of those complex products. Combination products offer a change in the performance of products to achieve a significant clinical benefit for the patients and populations.