Data monitoring committees (DMC) are conformed mainly by individuals with experience in the clinical and research field. DMCs are responsible for safeguarding the interest of study participants and mediating the technical and operational aspects of clinical trials. The independence of the DMCs from the sponsor and the research group is crucial to guarantee the accomplishment of an independent assessment of safety and integrity, being an impartial communication bridge. A monitoring strategy should be considered from the beginning according to the characteristics and relevance of the trial, as well a prior training should be conducted to guarantee a qualified job from the DMC members.