Today, some of the most challenging situations that affect our society are within the pharmaceutical industry. The false publicity, falsification of medicine, and lack of reports of adverse events of some of the drugs used in the medical field, among others, are some of the inconveniences that the Food and Drug Administration (FDA), being responsible for public health care, must face. The scope of the FDA's regulatory authority is vast.1 There are other agencies that have functions related to the FDA; for example, The Federal Trade Commission is the federal agency that regulates advertising, its mission is "to protect consumers by stopping unfair, deceptive or fraudulent practices in the marketplace."1 Knowing this, the postmarket safety, not only depends solely on one entity but on a team of agencies with different functions, whose job is to ensure safety measures that protect our society. This chapter will examine the government's implications, measures, and guarantees to ensure public health and postmarket drug safety.