S-3-hydroxyphenyl (N-hydroxycarbamamido) (diphenyl) ethanethioate derivatives were designed and docked into the crystal structure of 5-Lipoxygenase (5-LOX), a potential target for anti-inflammatory drugs.Four derivatives were found to have the same ability to inhibit 5-LOX activity as the antiinflammatory drug Zileuton.This study demonstrates the potential of computational methods, specifically molecular docking, in finding 5-LOX inhibitors.The results suggest that these derivatives could be developed into new compounds for treating inflammation.