The rapid depletion of fossil fuels in the last decade has negatively impacted the quality of the environment.This research exposes the simulation of two biorefinery scenarios to obtain highvalue chemical products: ethanol (Scenario 1) and methanol, propylene, and ethylene (Scenario 2).These alternatives were analysed for the possible implementation of an eco-industrial park using heat integration analysis, safety profiles, and environmental assessment.The potential of energy consumption reduction estimated using energy integration methodologies was higher in Scenario 2. After the safety analysis, Scenario 1 results were inherently more secure than Scenario 2. Therefore, the biorefinery needed to include the recovery of effluents from unwanted streams to enhance the production of high-value chemicals.Finally, the results showed that it is possible to successfully connect the biorefinery scenarios through an eco-industrial park to improve the competitiveness of intermediate sectors.