Background:The relationship between suboccipital musculature and cervical fascia abnormalities and myofascial pain syndrome in the presence of degenerative spine disease remains unclear based on current evidence. Case report:We present the case of a 46-year-old white male patient with severe chronic myofascial pain syndrome affecting his neck, thoracic and lumbar regions, left sciatica, and lower limbs, resulting in high mobility restriction.The initial MRI examinations revealed the presence of multiple degenerative discopathies.The patient underwent a single intervention of the Atlasprofilax method, which yielded remarkable results with complete remission of pain and a significant reduction in the frequency of virtually all symptoms.To assess the outcomes, various standardized measures were used, including the visual analog scale, patient global impression of change questionnaire, and three neck, thoracic, and lumbar disability questionnaires.Throughout the 9-month followup period, the patient exhibited highly positive outcomes in terms of pain reduction, symptom improvement, recurrence rate, and overall patient satisfaction.The symptoms of myofascial pain syndrome were nearly eradicated, leading to a substantial decrease in the use of painkillers with a remarkable improvement in the patient's mobility and overall quality of life. Conclusion:Further investigation is needed to explore the hypothesis that dysfunctions in the deep suboccipital musculature, deep cervical fascia, and upper cervical spine contribute to myofascial pain syndrome and degenerative spine disease.More clinical research is required to understand the role of the fascial continuum in degenerative spine disease and its impact on paravertebral muscle chains and intervertebral discs.The Atlasprofilax method, a non-invasive and conservative approach, shows promise as a potential therapeutic option in alleviating myofascial pain syndrome symptoms warranting further study.