Tendon functions in a complex multi-scale physiological environment to give flexibility and force to the wrist, and hence, it helps to the wrist to perform the daily motion as flexion, extension, adduction and abduction. Tendons often might suffer injuries that produce several types of damages on wrist motion abilities, such as tendon degeneration, pain, and they also can alter joint kinematics and affect other tendons as rotator cuff, achilles, flexor and extensor. This work aims to model and simulate the pre and post-surgical tendon transfer on the wrist using OpenSim 3.3. Tendon transfer is a useful approach focused on the restoring and improving the function of a damaged tendon in order to enhance motion abilities of the wrist. Besides a description of how the tendon force increases afterwards a tendon transfer, the impact of stiffness on the wrist motion is discussed through calculations based on inverse kinematics and dynamics. This experimental study provides a point-of-view to formulate hypotheses for future experimental studies associated to tendon transfer and provide insight to develop an assisting device design that complements experimental techniques.