The covid-19 pandemic has posed challenges worldwide, one of which is the deployment of mass vaccination programs. Prior planning and preparation for implementing mass vaccination processes have been essential to manage the covid-19 pandemic, including prioritization of vaccination, points of dispensing (PODs) network design, and PODs operation design. This study addresses some of these challenges, especially those related to the PODs operation design, offering alternatives for both the sequencing of activities and the allocation of the required personnel to meet a service goal. For this purpose, a field study was conducted in two Colombian cities observing four teams working in two mass vaccination PODs. Data collection focused on the identification of the implemented processes, the time measurement of each of their activities, the identification of the required personnel, and the corresponding level of service achieved daily. Then, a simulation model was set up and analyzed using a discrete event simulator for Business Process Modelling Notation (BPMN). The simulation exercise was useful to assist in the optimization of PODs by comparing alternatives for redesigning their processes, identifying possible bottlenecks, and analyzing the personnel requirements needed to run such facilities efficiently under different conditions. This approach can help public health managers assess and understand the impact of POD design on mass vaccination programs using different options and understand the usefulness of relying on process modeling and simulation.