Introduction:In the last two decades, advances in the percutaneous treatment of acute coronary syndrome have led to a reduction in its mortality, positioning percutaneous coronary intervention (PCI) as the treatment of choice.Percutaneous coronary intervention is a challenging procedure due to its higher risk of related complications and the prevalence of multiple comorbidities.Objective: To evaluate the baseline profile and clinical outcomes six months after a PCI in patients over 85 years old undergoing in-hospital coronary revasculari zation in the last three years.Materials and method: This is an "all-comers" registry including patients ≥ 85 years old treated with PCI in the last three years due to acute coronary syndrome.Results: We included 20 patients with a mean age of 90.3 years, 55% of whom were female.The main comorbidities were arterial hypertension (80%) and hyperlipidemia (58%).At the time of the intervention, 40% of the patients were diagnosed with ST-elevation coronary syndrome.Transradial PCI was performed on 70%, with successful target vessel revascularization in 90% of patients.There were four non-complicated vascular access-related bruises.Mortality was 0% over six months of follow-up.Conclusion: Percutaneous coronary intervention is a feasible and effective procedure with low complication rate in patients over 85 years of age diagnosed with acute coronary syndrome.