Objective: To compare the decreases between the appendectomy by single port vs. multiport laparoscopy and to establish if there is a difference in the risk of postoperative intra-abdominal collection.Method: Retrospective study was carried out using 116 medical records of patients undergoing laparoscopic appendectomy through a single port and multiport in two medical centers.Results: 12 (10.3%)patients developed an abdominal collection.No differences were found between the two techniques in terms of intra-abdominal collection development (p = 0.242), there was no difference between the two techniques in terms of intraoperative bleeding (p = 0.012), the surgical time was greater in the single-port group (17.4 min on average).62.5% of patients with bleeding > 50 mL developed intra-abdominal collection.Conclusions: There was no evidence of the superiority of either of the two interventions in complicated appendicitis, but it does confirm that single-port laparoscopic appendectomy is a safe, feasible, noninferior procedure and with similar complication rates compared to the conventional laparoscopic appendectomy technique.