Malignant hyperthermia (MH) is an acute hypermetabolic pharmacogenetic syndrome triggered by succinylcholine and inhaled anesthetics; the prevalence of MH episodes ranges from 1:10,000 to 1:220,000 cases per administered anesthesia; there is a deregulation in intracellular calcium homeostasis generating muscle rigidity, high energy expenditure, increased VO 2 , without timely treatment mortality is greater than 65% due to rhabdomyolysis, hyperkalaemia, increased CPK and multiple organ failure, with treatment specific decreases to 10%.We report the first case of malignant hyperthermia in preschool with extubation and early hospital discharge after the crisis; It is a 2-year-old female with no previous history diagnosed with syndactyly since birth.She is scheduled for correction of congenital deformity.She is performed under a balanced general anesthetic technique with sevoflorane and remifentanil.At the second hour of surgery, she presents symptoms compatible with malignant hyperthermia (tachycardia)., hypercapnia, hyperthermia) treatment was started according to the SCARE protocol with maintenance doses of dantrolene for 24 h, extubation at 24 h and discharge on the third day with follow-up in an outpatient clinic without sequelae.This case report highlights the importance of timely recognition of malignant hyperthermia crisis, the early initiation of pharmacological and non-pharmacological treatment during and after the crisis, the use of cognitive aids such as SCARE crisis protocols and the training of health personnel as a determining factor of the morbidity and mortality of these patients.