Background: Multimorbidity presents a challenge for healthcare systems due to its association with adverse clinical outcomes and increased healthcare expenditure. Given the limited available information, particularly in low- and middle-income countries, we characterize population multimorbidity patterns in Bogotá, Colombia.Methods: In a cross-sectional study we analyzed 16 million medical consultation records from the database of the National Health System in Bogotá, 2018. Using Network Analysis, we quantified the prevalence of multimorbidity in the population and characterized the most common comorbidities, stratifying the population based on age, sex, and socioeconomic status.Findings: The prevalence of multimorbidity in the population was 44·2%, which increased with age and was higher among women and individuals with private health insurance. For children and adolescents, the most common comorbidity was allergic and vasomotor rhinitis with asthma. Women aged 19-39 years commonly presented obesity with hypothyroidism, whereas men had obesity with disorders of lipoprotein metabolism. The most usual comorbidity in women and men aged 60 or more, was essential hypertension with disorders of lipoprotein metabolism. A few comorbidities showed a higher prevalence among people covered by public health insurance, with significant associations between traumas, specifically among men.Interpretation: The differences in the prevalence of multimorbidity and the associated comorbidities have implications for the planning of medical services at a population level, especially when addressing common comorbidities. It is essential to investigate whether lower multimorbidity prevalence among vulnerable people is related to biases in records or healthcare system inequities.Funding: We acknowledge the financial support received from the Universidad de Ibagué for the development of CSM's doctoral studies. The generous funding provided by the University has been instrumental in facilitating the progress of this research project and the preparation of the manuscript for submission.Declaration of Interest: We declare that there are no competing interests to disclose. We have no financial, personal, or professional conflicts of interest that could potentially bias the interpretation or presentation of our research findings.