Abstract Coffee parchment is one of the residues generated in coffee processing and has been poorly explored for value-added applications. It has been reported that coffee parchment has a high cellulose content (40–49%). Cellulose has been studied in many fields and specifically regenerated cellulose has been explored for many applications. Then, in this work a simple method for obtaining regenerated cellulose nanoparticles (RCNPs) from delignified coffee parchment, was determined. A complete physicochemical characterization of RCNPs obtained is presented, FTIR showed high cellulose purity, and XRD analysis showed high crystallinity of cellulose II. TEM images revealed that nanoparticles have spherical morphology. TGA showed good thermal stability and DLS allowed to determine the stability of suspension and the Z-average of the particles. The application of RCNPs on film formation was also evaluated when blended with PVA and Glycerol showing good mechanical properties with potential application on food packing.