A high-precision earthquake catalog was generated using source-specific station term and waveform cross-correlation techniques to interpret the crustal structure and deformation related to the tectonic setting in the Northwestern South America. The Panamá Chocó Block (PCB) is penetrating the Northwestern Andes causing crustal deformation and hence, fault interaction in the brittle regime leading to a high earthquake production. The Uramita Fault Zone (UFZ) behavior is a response to the accommodation of the PCB against the NW South American Plate showing an abrupt change in its strike.To the north, we find a lateral slip fault (strike = N52W and near vertical plane), which produced at least the historical Mutatá earthquake (1952-02-14, Mw = 5.9) (and likely also the Apartadó earthquake, 1977-08-30, Mw = 6.5) and a more recent earthquake sequence studied here in detail (2016-09-14, Mw = 6.2). The central segment of the UFZ strikes N12E and has also a vertical fault plane.The Murindó Fault (strike = N9W), which produced the great Murindó Earthquake (1992-10-18, Mw = 7.1, epicentral intensity XI) is characterized by its wide zone of brittle deformation behavior as the response of internal deformation of the Panamá-Chocó Block.Intermediate depth earthquakes are widely observed in the area, where we find evidence of a Caribbean slab subducting beneath Panamá to the north, and the subduction of the Nazca Plate to the south, showing high productivity within the Cauca Cluster with the presence of two finger-shaped mantle wedge earthquakes.