Objective To characterize and contextualize condom use in the transgender women (TW) population utilizing the HIV syndemic framework. Methods Studies reported condom-use frequency and syndemic factors associated with HIV risk in the TW population were searched in databases. We followed the PRISMA Extension for Scoping Reviews checklist. Results Social factors have a proven relationship with using condoms and HIV among TW. Syndemic factors, and how some of them reinforce others, deserve a specific analysis to develop strategies to face HIV among TW. Conclusions Analyzing a syndemic perspective allows to generate specific health intervention and prevention policies to protect the TW.