Numerous studies suggest that a relationship exists between certain personality variables and entrepreneurial orientation (EO). The aim of this study is to conduct a predictive study of personality variables that may influence entrepreneurial orientation. To do so, we use the following indicators: big five personality, hardiness, self-esteem, self-efficacy, impulsivity, pro-activeness, curiosity, internal locus control, optimism and pessimism. Participants in the study were 883 workers selected through non-probabilistic sampling and the data collected were processed with the SPSS 25.0 program. Our results determine the predictive capacity of personality variables, curiosity, and optimism in relation to EO. We conclude that OE can be predicted through the variables openness to experience, proactivity, curiosity-I, optimism and internal locus of control that explain greater variance when predicting entrepreneurial behaviour. This study contributes to wider knowledge of entrepreneurial orientation and the empowerment of variables that influence it.