The purpose of this article was to analyze the determinants of the financial impact of the pandemic on Colombian MSMEs, through an analysis of financial indicators of billing, profitability and liquidity of 1,498 Colombian MSMEs from different regions and economic sectors. For this, the structural equations methodology was used, based on information from the Ibero-American Observatory of MSMEs 2020-2021. The study presents evidence in favor of factors such as the change in commercial conditions of clients, organizational innovation and the competitive position of companies explain the financial impact of the Covid-19 pandemic on MSMEs in Colombia that managed to survive this situation, not being relevant the affectation of the commercial conditions of the suppliers and of financing, and the innovation in products and processes.