Background: The quality of recovery is a novel and important component of perioperative care. To measure this, the Quality of Recovery-15 scale has been previously validated. The aim of this study was to culturally, linguistically, and psychometrically adapt this scale to the Colombian Spanish language. Methods: After linguistic adaptation, a validation study of psychometric properties was carried out. These included validity, reliability, and responsiveness. The scale was administered after the administration of general anaesthesia. Validity was determined by correlating with the general recovery Verbal Analogue Scale (VAS), surgical risk, surgical duration and length of hospital stay. Structural validity was assessed by factor analysis. Test-retest and internal consistency were used to measure reliability. Results: 161 interviews were conducted with adults. A positive correlation was found between the score on the QOR-15S scale and the score on the VAS scale (r=0.51), as well as a negative correlation between the score on the QOR-15S scale and the duration of surgery (r=-0.47) and hospital stay (r=-0.62). The reliability of the scale was adequate. Cronbach's alpha was 0.74 and the CCC (Lin`s correlation concordance coefficient) was 0.99. Confirmatory factor analysis indicated that the scale in the Colombian Spanish version does not have a single domain, while exploratory factor analysis indicated that the scale may measure an additional factor. Conclusions: The QOR-15C scale for assessing the quality of recovery after general anaesthesia showed psychometric properties comparable to the English scale. This allows the scale to be considered for use in research as well as in clinical practice.