The 53% of the national territory, belonging to the Non-Interconnected Zones (ZNI) to the National Interconnected System (SIN) of Colombia (IPSE, 2021), have limited energy solutions to supply their energy consumption. For this reason, this paper aims to evaluate from a technical economic, environmental and social perspective, the design of an electric power generation system from anaerobic digestion of liquid waste from palm oil extraction, to supply the electricity demand of the municipality of Mapiripán, Meta. It was identified that the PBP of the area delivers approximately 198,000 tons of biomass residues and thanks to the bacterial activities 2,839,236 m3CH4/year are generated, which with the use of a 750 kWp generation system, an approximate annual energy generation of 5,832,000 kWh/year is available in terms of energy.