Multiple myeloma (MM) is a heterogeneous and incurable disease considered the second most common hematologic malignancy globally.The incidence, prevalence, and mortality worldwide are well-known thanks to the data reported by the International Agency for Research on Cancer (IARC) and by the Global Cancer Observatory GLOBOCAN.Our objective was to estimate the incidence, prevalence, and mortality of MM in Colombia in this work.The total population diagnosed with multiple myeloma (ICD Code 10 C900) during the 2008-2018 period was used, which was included in the RIPS (Registro Individual de Prestación de Servicios) in Colombia.The standardized incidence and prevalence rates for Colombia in 2018 were 1.79 (CI 1.76-1.81)and 8.97 x 100,000 inhabitants/year (CI8.94-8.99),respectively.The age-standardized mortality rate for Colombia was 1.39 x 100,000 inhabitants (1.36-1.41)(adjusted with the population of the United States).The prevalence was higher than that reported by other sources and is comparable with those of the whole world, North America, and Spain.MM must be one of the cancers in which epidemiology must prioritize and organize health cancer care due to the ageing population.