Pyometra is a bacterial infection with an accumulation of purulent exudate within the uterine lumen in intact female dogs.The diagnosis of this disease is made from the history, clinical and gynecological examinations, blood analyses, and ultrasonography of the abdomen.In this report, the clinical-surgical management of three cases of closed cervix pyometra is described.Three intact adult female dogs were presented to the veterinary emergency service because of general malaise, lack of appetite, and vomiting.The bitches showed estrus at least 3 weeks before the consultation, without vaginal discharge during this time.On clinical examination, the patients showed dehydration and apathy.Hematology, blood chemistry, and ultrasound were performed to confirm pyometra.Medical history, clinical, hematologic and chemistry findings, and abdominal ultrasonography were all consistent with a diagnosis of closed cervix canine Pyometra.Determinations of C-reactive protein were important to know the severity of inflammatory response before and post-surgery.Moreover, intraabdominal use of physiologic saline solution plus metronidazole and amoxicillin prevents secondary infections and decreases the inflammatory response.It concludes that the present report describes clinical and surgical management of closed cervix pyometra for optimizing monitoring, treatments, and saving the lives of patients with this disease.