Currently, the use of Cannabis Sativa L and cannabidiol (CBD) is being studied as a treatment or adjunct in the management of substance abuse dependence in various animal models of addiction. In the present research, a murine model was developed and evaluated for the behavioral investigation of smoked cocaine dependence using the Conditioned Place Preference (CPP). This model was then used to evaluate CBD and a standardized non-psychoactive cannabis extract as a treatment for this type of addiction. In the first experiment (n=20), a comparison was made between the extinction times in the CPP of individuals conditioned with 15 mg/kg cocaine hydrochloride (COC) or the combination of methyl-ecgonidine (AEME) and COC at doses of 15 mg/kg each. In the second experiment (n=55), the use of CBD (20 mg/kg and 60 mg/kg) and a non-psychoactive cannabis extract (20 mg/kg) was evaluated in animals conditioned with AEME-COC (15 mg/kg each) on extinction and reconsolidation indicators. It was shown that compared to the COC group, conditioning produced by AEME and COC administration could lead to an increase in the extinction time in the proposed CPP model (up to 10 weeks). The results demonstrate that CBD does not significantly decrease extinction or reconsolidation indicators in the CPP produced by AEME-COC administration at the proposed doses, while the non-psychoactive cannabis extract reduces the extinction time of conditioned behavior (p=0.025 post hoc ANOVA, α=0.05) and reduces reconsolidation by stressful sounds (60% additional compared to the control group). This study demonstrates that non-psychoactive cannabis extract may be promising as a treatment for smoked cocaine dependence, while isolated CBD does not have the same effectiveness