The fundamental role of prebiotics, probiotics, and the synergistic combination of these (synbiotics) on human health has contributed to a growing interest in the research and development of these products, which can be specifically designed to produce bioactive molecules with functions and specific health benefits. However, challenges such as the design of bioreactors for their production, selection of suitable combinations of prebiotics and probiotics, assurance of their viability, as well as the development of methodologies for the evaluation of their benefits represent a source for continuous improvement and innovation in this area. The purpose of this chapter is to identify and analyze the major advances in research and development of synbiotic products. The multiple health benefits attributed to the action of these products are explored, as well the advances in the design of bioreactors for their production, use of microencapsulation, nanotechnology, and other technologies to ensure their viability and modification of its functionality, applications in various fields such as dermatological diseases, animal feed, and functional foods. Recent advances in synbiotics have allowed the development of better applications in terms of viability, sustainability, and effectiveness, as well as a greater understanding of their beneficial properties, opening new opportunities in the fields of nutrition, food industry, among others.