<h3>Background</h3> Comorbidities and multimorbidity, often complicate the disease course of patients with systemic lupus erythematosus. <h3>Objectives</h3> The objetive was to estimate de prevalence of comorbidities in patients with systemic lupus. erythematosus using administrative databases in Colombia. <h3>Methods</h3> This study was carried out using databases generated based on technical studies conducted by the Colombian Ministry of health. A person in the database was considered a patient with SLE if she met the following operative definition: a patient who has been classified with an ICD-10 diagnosis code which corresponds to SLE in an inpatient claim or if she has been classified at least two times in outpatient claims, with a difference of minimum 30 days and less than 2 years, with a ICD-10 diagnosis code corresponding to SLE. In turn, a control group matched by age and sex was randomly selected to evaluate the difference in the frequency of comorbidities in both groups. <h3>Results</h3> We previously published the prevalence of patients with SLE, that ranges between 41.65 and 54.47 (cases/100 000), which is lower than other Latin American countries. Using the operative definition of SLE, 5527 patients were selected, and 22108 controls paired by sex and age, the average age was 43 years old in both groups, the average of comorbidities was 3.5 (SD 1.8) for SLE patients and 1.7 (SD 1.5) for control group, we found a higher prevalence for. most comorbidities, particularly those related to cardiovascular disease, kidney disease and depressive disorders in subjects with SLE compared to the control group Table 1. Table Prevalence of comorbidities by group. <h3>Conclusion</h3> SLE patients had a burden of comorbidities, and the prevalence of multiple comorbidities were higher compared to matched controls. <h3>Reference</h3> [1]Gergianaki I, Garantziotis P, Adamichou C, Saridakis I, Spyrou G, Sidiropoulos P, Bertsias G. High Comorbidity Burden in Patients with SLE: Data from the Community-Based Lupus Registry of Crete. J Clin Med. 2021 Mar 2;10(5):998. doi: 10.3390/jcm10050998. PMID: 33801229; PMCID: PMC7957898. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.