<h3>Background</h3> The co-occurrence of lupus (SLE) and tropical infections has been poor studied, this group of infections, prevalent in the tropics could simulate or trigger disease activity, however, some studies suggest that malaria infection could confer protection from the development of SLE, that is for this reason, studies are required to characterize this population. <h3>Objectives</h3> The objective of our study was to estimate de frequency of tropical infections in patients with SLE using administrative databases in Colombia. <h3>Methods</h3> This study was carried out using databases generated based on technical studies conducted by the Colombian Ministry of health. For the present study, databases provided contained information from 2014 to 2017, and contains the information of approximately 20 million affiliates. A person in the database was considered a patient with SLE if she met the following operative definition: a patient who has been classified with an ICD-10 diagnosis code which corresponds to SLE in an inpatient claim or if she has been classified at least two times in outpatient claims, with a difference of minimum 30 days and less than 2 years, with a ICD-10 diagnosis code corresponding to SLE. In turn, a control group matched by age and sex was randomly selected to evaluate the difference in the frequency of tropical infections in both groups. The variables considered in this part of the study were classified in two main groups: demographic, and clinical. Demographic variables include age, sex, and department (territorial entity). As for tropical infections we use the ICD-10 diagnosis code and to estimate the prevalence of tropical infections. <h3>Results</h3> Using the operative definition of SLE, 5527 patients were selected, and 22108 controls paired by sex and age, the average age was 43 years old in both groups, the frequency of tropical infections was low in both groups, however, we documented a higher frequency of malaria and dengue in the group of subjects with SLE when compared to controls. <h3>Conclusion</h3> SLE patients had similar frequency of tropical infections compared to matched controls, except for malaria and dengue infections. <h3>Reference</h3> [1]Yasri, S., &amp; Wiwanitkit, V. (2015). Dengue and lupus: The problem of co-occurrence. <i>Asian Pacific Journal of Tropical Disease</i>, <i>5</i>(12), 1007–1008. https://doi.org/10.1016/S2222-1808(15)60974-4 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.