The study focused on conducting a meta-analytic review of three variables psychoneuroimmunology, emotions, and the immune system, intending to find a relationship between them. The methodology was the PRISMA statement with inclusion criteria: production of the last five years, full text, exclusion criteria: book chapters, reviews, editorials, letters to the editorials, as well as systematic and meta-analytic reviews; a formula was created from the variables with Boolean operators (AND, OR, NOT) in databases: Web of Science, PubMed and Elsevier. The first sweep denotes (n=2237) articles and after the application of the screening, the final sample was (n=26).