<h3>Background</h3> Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases that have some key features in common. According to ASAS, this condition is classified into three main disease groups: radiographic axial SpA (r-AxSpA), non-radiographic axial SpA (nr-axSpA), and peripheral SpA (pSpA). All patients with SpA with predominantly axial involvement are considered to have axial SpA, patients with significant radiographic sacroiliitis according to the modified New York criteria have r-axSpA. Patients without radiographic sacroilitis but with axial disease have nr-axSpA. More information is needed about the difference between these groups, especially in other populations like ours. <h3>Objectives</h3> The objectives of this study are to systematically compare the demographic, clinical, and laboratory characteristics, disease onset, and physical examination findings of patients with r-AxSpA and nr-AxSpA; and identify factors that could predict a subtype of the disease. <h3>Methods</h3> Data from 148 patients over 18 years collected between 1998 and 2005 from Hospital General de México and Instituto Nacional de Ciencias Médicas y Nutrición. Patients classified according to ASAS criteria. We selected patients with nr-AxSpA and r-AxSpA and compared, clinical, demographic, and clinimetric variables. Logistic regression analysis was applied to identify the parameters associated with r-AxSpA or nr-AxSpA. Exclusion criteria included patients under biologic treatment. <h3>Results</h3> This study included 148 adult Mexican patients; general characteristics are exposed in table 1. HLA-B*27 was present in 57% of patients. Patients with nr – AxSpA were more women (41.4% vs 21.8%; P &lt;0.05), with less presence of HLA-B27 (54.3% vs 92.7%, P &lt; 0.05) compared to the r – axSpA group. R-AxSpA patients were younger at symptom onset (16 vs. 21 years; P &lt; 0.01) than nr – axSpA (Image 1). Patients with nr – AxSpA had more history of infection preceding disease onset (32.9% vs 9.1%; P &lt; 0.05), and less frequency of uveitis (10% vs 25.5% P &lt; 0.05), more dactylitis (12.9% vs. 0%, P &lt; 0.01), less painful entheses (3 vs. 6 P &lt; 0.01), and less axial enthesopathy (1 vs. 4 P &lt; 0.05) than r-AxSpA patients. The measures of thoracic expandability, modified Schober, right and left flexion test, were significantly lower in r-AxSpA group than in the nr-AxSpA group, p &lt; 0.01). patients with r-AxSpA had higher Bath Ankylosing Spondylitis Functional Index (BASFI) (4.8 vs 2.9%; P &lt; 0.01), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (5.2 vs 4.1; P &lt; 0.01), Dougados functional index (14% vs 7%; P &lt; 0.05) than nr – AxSpA. Logistic regression shows that the factors that most influence the presentation of r-AxSpA are the history of uveitis (OR 14, 95% CI 2.3-85), HLA-B27 (OR 7, 97, 95% CI, 2.96-122), gender (male) (OR 6.16, 95% CI, 1.47-25.7), axial enthesopathy count (OR 1.17 95% CI, 1.03-1.33). The history of infection is a protective factor against radiographic disease (OR 0.19, 95% CI 0,04 – 0,91). <h3>Conclusion</h3> This study provides insight into the differences that may affect the prediction of radiographic progression in patients with nr-AxSpA. We found that patients with radiographic disease had a younger age of presentation, mostly male, higher prevalence of HLA-B27, more history of uveitis, fewer episodes of dactylitis, more axial enthesopathy, and higher disease activity. Table 1 <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.