This research aims to provide precise data on risk behaviors and protective factors for the health of secondary and high school students at a Colombian educational institution. The study has a quantitative approach with a descriptive scope, a convenience sampling was carried out thattook as a sample of 656 students who received authorization from their parents and agreed to answer the voluntary, anonymous, and confidential survey. The 10 modules of the Global School Hkealth Survey (GSHS) were applied, and this article presents the results regarding the modules of tobacco use, drug use, sexual behaviors, and mental health.