Abstract A determination of the jet energy scale is presented using proton–proton collision data with a centre-of-mass energy of $$\sqrt{s}=13$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:mrow> </mml:math> TeV, corresponding to an integrated luminosity of 140 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow /> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:math> collected using the ATLAS detector at the LHC. Jets are reconstructed using the ATLAS particle-flow method that combines charged-particle tracks and topo-clusters formed from energy deposits in the calorimeter cells. The anti- $$k_\textrm{t}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>k</mml:mi> <mml:mtext>t</mml:mtext> </mml:msub> </mml:math> jet algorithm with radius parameter $$R=0.4$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mo>=</mml:mo> <mml:mn>0.4</mml:mn> </mml:mrow> </mml:math> is used to define the jet. Novel jet energy scale calibration strategies developed for the LHC Run 2 are reported that lay the foundation for the jet calibration in Run 3. Jets are calibrated with a series of simulation-based corrections, including state-of-the-art techniques in jet calibration such as machine learning methods and novel in situ calibrations to achieve better performance than the baseline calibration derived using up to 81 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow /> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:math> of Run 2 data. The performance of these new techniques is then examined in the in situ measurements by exploiting the transverse momentum balance between a jet and a reference object. The b -quark jet energy scale using particle flow jets is measured for the first time with around 1% precision using $$\gamma $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>γ</mml:mi> </mml:math> +jet events.