Introduction:Lidocaine is a local anesthetic agent, with intravenous route indications for use in contexts different from symptom control in oncologic patients.Evidence regarding its usefulness in neuropathic pain and refractory pruritus exists.This review aims to describe available evidence supporting its use in those aforementioned conditions.Conclusion: Lidocaine infusion has demonstrated effectiveness as a therapeutic intervention for neuropathic pain and refractory pruritus.It is required a larger body of evidence for its standardized application.