Abstract Objective Persistent postural-perceptual dizziness (PPPD) is a chronic vestibular condition that produces non-spinning vertigo, dizziness and unsteadiness which leads to an altered quality of life (QoL). Little is known about QoL assessment using questionnaires such as EQ-5D in hispanic patients with PPPD compared to those with other vestibular disorders. Methods We conducted a prospective study in using EQ-5D and VAS in patients with PPPD and patients with other vestibular disorders such as vestibular migraine, Ménière’s disease and Benign paroxysmal positional vertigo without PPPD. An EQ-5D- VAS Index calculator was used to convert results to a single utility index using country specific value sets. Statistical analysis included descriptive analysis and lineal regression. Results Fifty-one patients with PPPD and sixty patients with other vestibular disorders without PPPD were included. Mobility (51% vs 49, p = 0.001), self-care (27.5% vs 2%, p = 0.025) and anxiety/depression (47.1% vs 37.5%, p = 0.0001) were the most common affected items in patients with PPPD than those without this disorder. Worse EQ and VAS scores were seen in patients with PPPD when compared to other vestibular conditions (p = 0.027 vs p = 0.148). Increased EQ-5D and VAS scores were seen in older patients with PPPD. Conclusion Patients with PPPD presented worse EQ5D and VAS scores compared to those without PPPD. As age increased worse EQ-VAS scores were found. Mobility, self-care, and anxiety/depression scores were found in patients with PPPD than those with other vestibular conditions. Further prospective studies focused in QoL including therapeutic and rehabilitation outcomes are suggested. Level of Evidence : Prospective Study