Objective: Design a comprehensive intervention protocol with ecological validity for school-age children diagnosed with hemiparesis associated with cerebral palsy in Cali-Colombia.Method and materials: Mixed study carried out through a sequential explanatory design of two moments (DEXPLIS-2); which was organized in a quantitative stage (descriptive) and a qualitative stage (ethnomethodological).Bibliographic reviews (n=30), structured interviews with professionals (n=50), semistructured interviews with family members (n=2), companions (n=2), caregivers (n=2), children (n=2) were carried out.and experts with experience in neurorehabilitation (n=5).The instruments included the RAE format, perception survey, conversation script, and validation format.Results: Three exercise modules (sensory, sensorimotor, integrative, productive, facilitators) connected in a twoand three-dimensional way, organized in three levels, appropriate to the context in terms of materials, instructions, and space, and with content validation (RCV = 0.90).Conclusions:The integral intervention protocols have as characteristics, (1) scientific evidence that supports the performance of the activities; (2) experiences of the actors on the materials and instructions to be used in the intervention; (3) recognition of the most favorable context to develop them; and (4) experiential validation of each exercise by experts.