This work aims to develop a robust model predictive control (MPC) based on the active disturbance rejection control (ADRC) approach by using a discrete extended disturbance observer (ESO). The proposed technique uses the ADRC approach to lump disturbances and uncertainties into a total disturbance, which is estimated with a discrete ESO and rejected through feedback control. Thus, the effects of the disturbances are attenuated, and a model predictive control is designed based on a canonical model free of uncertainties and disturbances. The proposed control technique is tested through simulation into a robotic autonomous underwater vehicle (AUV). The AUV’s dynamic model is used to compare the performance of a classical MPC and the combined MPC-ADRC. The evaluation results show evidence of the superiority of the MPC-ADRC over the classical MPC under tests of reference tracking, external disturbances rejection, and model uncertainties attenuation.