Blood circulation between the conceptus and its mother is key for a healthy pregnancy and, consequently, an adequate lamb development and better expression of its productive characteristics. Vessels can present small diameters with slow blood flow in the utero-placental complex, which make necessary the development of technological alternatives to obtain reliable data on the maternal-fetal blood circulation. Contrast-enhanced ultrasound technology is an option to address this problem. In this study, this technology was used to assess the characteristics of blood flow in the uterus and placentomes in ewes. The contrast medium did not cause any harm to the ewes or the lambs. The perfusion pattern of the contrast medium in the uterus and placentomes was centrifugal and homogeneous. During the ultrasonography evaluation period, there was a progressive decrease in intensity of pixels, time to peak and mean transit time in the uterus and placentomes. Also, there was a similar decrease in transmission time and area under the curve. This work brings important and unpublished information about the normal embryonic/fetal development throughout the gestation of ewes.